![]() ![]() Therefore, in the present study, the microecological indicators of vaginal secretions of childbearing-age women with cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma (CSCC) were evaluated. However, it remains to be determined whether local changes in the microecology and immunity of the vagina affect the pathogenicity and progression of HPV infection, since the cervix is exposed in the vagina. In addition to HPV infection, other synergistic factors also affect the pathogenicity of HPV infections. Studies have revealed that high-risk human papillomavirus (HPV) infection is the major cause of cervical lesions, and that 80% of women have been infected with HPV in their lifetime, but only a small number of these population have developed cervical lesions. The reduction of dominant Lactobacillus in the vagina, impairment of H 2O 2 function, flora ratio imbalance, pathogen infections, reduction in IL-2/IL-10 ratio, and changes in SIgA and IgG levels could all be potential factors that influenced the pathogenicity of HPV infection and the occurrence and development of cervical lesions. ConclusionsĪs the degree of cervical lesions increased, IL-2 decreased, IL-10 increased and IL-2/IL-10 decreased, while SIgA and IgG were elevated. ![]() (2) Differences in the ratio of IL-2 and IL-10 in the female genital tract among all research groups and the control group were statistically significant ( P < 0.0001). Moreover, the positive rate of H 2O 2 decreased, while the positive rates of SNa and GADP increased. Furthermore, the incidence of HPV, trichomonads, clue cell and Chlamydia infection increased. As the degree of cervical lesions increased, the number of Lactobacillus decreased, and there was an increase in prevalence of bacterial imbalance, and the diversity, density and normal proportion of bacteria was reduced. The results is that: (1) Differences in evaluation indexes of vaginal microecology among all research groups and the control group were statistically significant ( P < 0.0001). Furthermore, the concentrations of SIgA, IgG, IL-2 and IL-10 in vaginal lavage fluid, as well as the presence of HPV, mycoplasma and Chlamydia in cervical secretions, were detected. The microbiological indexes of vaginal secretions were evaluated. In addition, 100 healthy females were enrolled and assigned as the control group. ![]() These patients were assigned as the research groups. Among these patients, 136 patients had LSIL, 263 patients had HSIL and 33 patients had CSCC. MethodsĪ total of 432 patients were included in this study. This study aims to investigate the difference in vaginal microecology, local immunity and HPV infection among childbearing-age women with different degrees of cervical lesions. ![]()
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